My research lab primarily employs X-ray crystallography, along with various biophysical and biochemical techniques, to scrutinize the 3D architecture of protein-RNA interactions. Additionally, we delve into the molecular underpinnings governing RNA-protein interactions in RNA silencing and epigenetic processes.
Protein-RNA complexes produced in our lab.
The crystalline form of PAZ domain from human Argonaute 1, encapsulating a small RNA and its recognition by the 3' end of the RNA.
The structural composition of AfPiwi-siRNA complex, featuring specific interaction with the 5' phosphate group and nucleotide.
The arrangement of Arabidopsis small RNA specific methyltransferase Hen1, bound to a miRNA duplex and highlighting the underlying mechanism of substrate recognition.
